Learning Goal: I’m working on a pharmacology writing question and need an explan

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Learning Goal: I’m working on a pharmacology writing question and need an explanation and answer to help me learn.Assignment 12 – (Drug: AMLODIPINE)- Final Report: Turn in finalized research report. As before, your document should reflect an understanding of all the course material and how it relates to your drug (AMLODIPINE) of interest; it should include improved content from the first & second drafts as well as new content that covers the newest material in class. In particular, are there any important pharmacogenetics/pharmacogenomics related to your drug? Are there subpopulations of patients that should avoid this medication or require extra attention when prescribed this medication? Why?
Your paper is expected to be clear to read and have proper citations for anything you’ve written. This assignment must be typed and submitted electronically in MS Word (.doc or .docx) or PFD format.Final research paperFinal research paperCriteriaRatingsPts1.Drug propertiesPhysical properties of drug & how it’s typically formulated & marketed.10 to >8.0 ptsFull Marks8 to >5.0 ptsVery good5 to >2.0 ptsOkay, but notable gaps2 to >0.0 ptsWeak0 ptsNo Marks10 pts2.Drug use & FDA approvalInformation on patient populations, approved & off-label uses, any notable FDA regulations10 to >8.0 ptsFull Marks8 to >5.0 ptsVery good5 to >2.0 ptsOkay, but notable gaps2 to >0.0 ptsWeak0 ptsNo Marks10 pts3.History & Background on drug, including aspects of its discovery & optimization. Are there related compounds? Is it derived from a natural product?10 to >8.0 ptsFull Marks8 to >5.0 ptsVery good5 to >2.0 ptsOkay, but notable gaps2 to >0.0 ptsWeak0 ptsNo Marks10 pts4.Pharmacokinetics General pharmacokinetic properties of the drug, including routes of drug administration, metabolic pathways, routes of eliminations and standard PK parameters. Any unusual PK considerations for your drug?10 to >8.0 ptsFull Marks8 to >5.0 ptsVery good5 to >2.0 ptsOkay, but notable gaps2 to >0.0 ptsWeak0 ptsNo Marks10 pts5.Pharmacodynamics General pharmacodynamic properties of the drug, including targets for therapeutic effects and off-targets that may contribute side effects, effects of drug at targets (agonist? antagonist?) Any unusual PD considerations for your drug?10 to >8.0 ptsFull Marks8 to >5.0 ptsVery good5 to >2.0 ptsOkay, but notable gaps2 to >0.0 ptsWeak0 ptsNo Marks10 pts6.Pharmacogenetics/Pharmacogenomics Are there any important pharmacogenetics/pharmacogenomics related to your drug? Are there subpopulations of patients that should avoid this medication or require extra attention when prescribed this medication? Why?10 to >8.0 ptsFull Marks8 to >5.0 ptsVery good5 to >2.0 ptsOkay, but notable gaps2 to >0.0 ptsWeak0 ptsNo Marks10 pts7.Clarity of presentation + citations (ACS FORMAT is preferable) Is the information in the current draft clear & easy to follow? Is the information in the document from reputable sources and clearly, properly cited?20 to >16.0 ptsFull Marks16 to >10.0 ptsVery good10 to >4.0 ptsOkay, but notable gaps4 to >0.0 ptsWeak0 ptsNo Marks20 ptsTotal Points: 80note: first and second drafts are attached in files, All the requirements must be addressed as mentioned criteria ( 1-7 requirements need to mentioned with headings and sub-headings).

 

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